Investec Champions Cup Pool Four
Northampton Saints (14) 50
Tries: Sleightholme 2, Hendy 3, Pollock, Coles, Kemeny Cons: Smith 5
Pretoria Bulls (5) 5
Tries: Jacobs
George Hendy scored a hat-trick as the Saints made it maximum points from their opening two European games with an eight-try hammering of Pretoria.
Sleightholme scored two tries and Pollock scored the fourth try inside an hour as a dominant Northampton side cut loose in the second half.
The Bulls were within touching distance with the score fourteen-five at the break but a sin-binning to forward Alulutho Tshakweni in the 53rd minute for a unnecessary trip proved very costly and they did not score a point in the final forty minutes.
International Smith added 10 points from the tee as Saints moved to the summit of Pool Four on superior points difference from holders Bordeaux with both sides on 10 points.
The manner of this win, coming after a 35-27 victory on the road at Pau last week, means last season's runners-up Northampton could not have hoped for a more ideal beginning as they look to improve on that this season.
Pretoria's number ten Kade Wolhuter missed an early shot at goal before Saints took the lead when Henry Pollock broke before feeding Ollie Sleightholme who showed his pace to race clear to the line.
But an error from Sleightholme let the Bulls back in as the ball slipped from his grasp in contact, allowing Pretoria winger Stravino Jacobs to kick on and show electric speed of his own to score after 22 minutes.
Ten minutes later, Northampton had their second try as quick hands from Alex Mitchell at the base of a ruck and then Fin Smith sent Hendy over to make it 14-5 at the break.
Northampton were on top in possession and territory and were being aided from Bulls fly-half Kade Wolhuter who failed to find touch with penalty kicks to reinvite pressure onto the visitors.
That told after 48 minutes when Smith was again the architect, darting inside to wrong-foot the advancing defence before delivering a sweet left-footed kick over the line for George Hendy to grab his second and Northampton's third score.
Pretoria forward Tshakweni was then sin-binned for a trip on Iyogun. Tshakweni was insistent he had been reacting to a trip momentarily before by Iyogun but the incident from the Northampton substitute was ruled unintentional when reviewed by the officials.
Northampton seized the opportunity of having the numerical advantage to clinch the try bonus point through Henry Pollock before Coles and Sleightholme scored as the hosts registered three tries in five minutes.
George Hendy completed his hat-trick with twelve minutes left on the clock and Josh Kemeny walked over for the eighth and final try of an outstanding afternoon for Northampton in the dying moments.
The leading pair in the pool will face off in a rerun of the previous season's final when the Investec Champions Cup returns in January as Saints travel to Bordeaux. Northampton then round off the group phase with a home game against the Scarlets on 18 January.
The Bulls, who have one point from two matches, welcome Bristol Bears in their next outing before an away trip face Pau.
Northampton: Furbank; Sleightholme, Hutchinson, Dingwall, Hendy; F Smith, Mitchell; Fischetti, Wright, Davison, Coles, Van der Mescht, Kemeny, Pearson, Pollock
Replacements: R Smith, Iyogun, Kundiona, Munga, Prowse, Graham, James, Thame
Bulls: Williams; Petersen, Gans, Vorster, Jacobs; Wolhuter, Burger; Tshakweni, Van der Merwe, Smith, Wiese, Van Heerden, Coetzee, Ludwig, Louw
Replacements: Else, Sithole, Mchunu, Gumede, Carr, Papier, Johannes, Van Niekerk
Yellow card: Tshakweni (53)
Referee: Hollie Davidson (Sco)
Assistant referees: Rob McDowell (Sco) and Dave Sutherland (Sco)
TMO: Mike Adamson (Sco)
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